In 2022,Wang, Linhua; Zheng, Xuesong; Zheng, Qinze; Li, Zhenlong; Wu, Jian; Gao, Ge published an article in Organic Letters. The title of the article was 《Thioether-Assisted Cu-Catalyzed C5-H Arylation of Imidazo[1,5-a]pyridines》.Application In Synthesis of 4-Iodopyridine The author mentioned the following in the article:
A series of ethylthio (hetero)arylimidazo[1,5-a]pyridine derivatives I (R = 4-methylphenyl, pyridin-4-yl, 1-methyl-1H-indol-5-yl, etc.; R1 = H, Cl, Br, Me, Ph, 4-methoxyphenyl, 4-trifluoromethylphenyl; R2 = H, 6-Cl, 7-Me) was prepared via Cu-catalyzed regioselective C5-H arylation of imidazo[1,5-a]pyridines I (R = H) with aryl iodides RI with the assistance of an ethylthio group at the C3 position. This directing group could be easily removed to furnish a range of 5-(hetero)arylimidazo[1,5-a]pyridine derivatives e.g., II. The reaction tolerates a variety of functionalities and is compatible with sterically hindered substrates. After reading the article, we found that the author used 4-Iodopyridine(cas: 15854-87-2Application In Synthesis of 4-Iodopyridine)
4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.Application In Synthesis of 4-Iodopyridine
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com