Wang, Jian; Li, Lianjie; Chai, Minxue; Ding, Shumin; Li, Jing; Shang, Yongjia; Zhao, Haixia; Li, Dan; Zhu, Qiang published an article in 2021. The article was titled 《Enantioselective Construction of 1H-Isoindoles Containing Tri- and Difluoromethylated Quaternary Stereogenic Centers via Palladium-Catalyzed C-H Bond Imidoylation》, and you may find the article in ACS Catalysis.Reference of 4-Iodobenzaldehyde The information in the text is summarized as follows:
An intermol. enantioselective synthesis of 1H-isoindoles containing tri- and difluoromethylated quaternary stereogenic centers through a palladium-catalyzed desym. C-H bond imidoylation has been developed. α,α-Diaryl tri- and difluoroethylated isocyanides acted as powerful precursors of chiral 1H-isoindoles, in which the fluoroalkyl group was proven to play a crucial role in both the stereochem. and reaction efficiency. In addition, an allene insertion cascade was realized, offering rapid access to diverse C1-tethered bis-heterocyclic scaffolds with good yields and high enantioselectivities. The reactions proceeded smoothly under mild conditions with low catalyst loadings. The results came from multiple reactions, including the reaction of 4-Iodobenzaldehyde(cas: 15164-44-0Reference of 4-Iodobenzaldehyde)
4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Reference of 4-Iodobenzaldehyde
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com