Application of 15854-87-2In 2022 ,《Bromide as the Directing Group for β-Arylation of Thiophenes》 was published in Synthesis. The article was written by Wang, Cai-Xia; Sheng, Fei-Fei; Liu, Kai-Hui; Gu, Jian-Guo; Shen, Kang; Sun, Zheng-Yi; Hong, Kunlun; Zhang, Hong-Hai. The article contains the following contents:
Direct β-arylation of thiophene derivatives with bromide as directing group was disclosed. The reaction was conducted with PdCl 2/( p-tolyl) 3P as catalyst, silver carbonate as additive and aryl iodide as coupling partner, affording brominated biaryl compounds as product. Control experiments indicated that the presence of bromide group enhances the reactivity of the C-H bond, enabling β-arylation. Furthermore, the C-Br bond was easily converted into many useful functional groups through a wide range of methodologies. The mechanistic study suggested that silver salt plays a key role in the C-H bond-activation step. The results came from multiple reactions, including the reaction of 4-Iodopyridine(cas: 15854-87-2Application of 15854-87-2)
4-Iodopyridine(cas: 15854-87-2) is a halogenated heterocycle that is a building block for proteomics research. 4-Iodopyridine is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists.Application of 15854-87-2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com