In 2022,Tang, Baoxin; Hua, Ruimao published an article in Molecules. The title of the article was 《Cu(I)/Pd(II)-Catalyzed Intramolecular Hydroamidation and C-H Dehydrogenative Coupling of ortho-Alkynyl-N-arylbenzamides for Access to Isoindolo[2,1-a]Indol-6-Ones》.Quality Control of 2-Iodobenzoic acid The author mentioned the following in the article:
An efficient, atom-economic and one-pot synthesis of isoindolo[2,1-a]indol-6-ones I [R = H, 9-F, 9-MeO; R1 = H, 2-Me, 2-i-Pr, 2-MeO, 2-CF3, 2-CN; Ar = Ph, 2-MeC6H4, 4-MeOC6H4, etc.] via CuI/Pd(OAc)2-catalyzed intramol. hydroamidation of alkynyl group, and C-H dehydrogenative coupling of ortho-alkynyl-N-arylbenzamides had been developed. This transformation occurs with the use of oxygen as the oxidant, and water was the only byproduct. The reaction showed a high tolerance to a variety of functional groups, and affords isoindolo[2,1-a]indol-6-ones I in good to high yields. The experimental part of the paper was very detailed, including the reaction process of 2-Iodobenzoic acid(cas: 88-67-5Quality Control of 2-Iodobenzoic acid)
2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Quality Control of 2-Iodobenzoic acid
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com