《Lewis Acid-Free Ynoate-Mediated Chemoselective Reduction of Carboxylic Acids to Primary Alcohols》 was published in ChemistrySelect in 2020. These research results belong to Sun, Feixiang; Feng, Huangdi; Huang, Liliang; Liu, Weiping. Formula: C7H5IO2 The article mentions the following:
Economical and facile catalytic reduction process of carboxylic acids for the synthesis of alcs was reported. This pyridine-catalyzed strategy operates through addition of carboxylic acids with Me propiolate followed by NaBH4 reduction or unexpected ester exchange, provided the corresponding primary alcs. and esters, resp. A range of carboxylic acids bearing other reductive groups (e. g., halogen, cyano, nitro, ester and double bond) were accessed with uniformly high chemoselectivity. The use of environmentally benign, convenient and safe procedure also makes this catalytic protocol attractive for practical application. In addition to this study using 4-Iodobenzoic acid, there are many other studies that have used 4-Iodobenzoic acid(cas: 619-58-9Formula: C7H5IO2) was used in this study.
4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Formula: C7H5IO2 Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com