Marchese, Austin D.; Adrianov, Timur; Kollen, Martin F.; Mirabi, Bijan; Lautens, Mark published an article in 2021. The article was titled 《Synthesis of Carbocyclic Compounds via a Nickel-Catalyzed Carboiodination Reaction》, and you may find the article in ACS Catalysis.Computed Properties of C7H5IO2 The information in the text is summarized as follows:
A scalable nickel-catalyzed carboiodination reaction generating 6-membered carbocycles I [R1 = H, 7-Me, 5-F, etc.; R2 = Me, n-Pr, Bn; R3 = CO2Me, CO2Et, CO2t-Bu, CO2Ph; R4 = CO2Me, CO2Et, CO2t-Bu, CO2Ph] was reported. NiI2 and P(OEt)3 as the ligand and reducing agent, provided decorated iodomethyl-tetrahydronaphthalenes I in up to 94% yield. The impact of varying electronic and steric parameters on the reaction were reported and a nonlinear Hammett plot was obtained, supporting a change in rate-determining step from oxidative addition to reductive elimination. Exptl. and DFT studies suggested the malonate group might stabilize a nickel oxidative-addition complex. A variety of heteroatom-containing nucleophiles and medicinally relevant heterocycles were easily incorporated into the products via simple SN2 chem. In addition to this study using 2-Iodobenzoic acid, there are many other studies that have used 2-Iodobenzoic acid(cas: 88-67-5Computed Properties of C7H5IO2) was used in this study.
2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Computed Properties of C7H5IO2 Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com