《Trifluoromethylation of Benzoic Acids: An Access to Aryl Trifluoromethyl Ketones》 was written by Liu, Xue; Liu, Long; Huang, Tianzeng; Zhang, Jingjing; Tang, Zhi; Li, Chunya; Chen, Tieqiao. Electric Literature of C7H5IO2This research focused ontrifluoromethyl ketone preparation green chem; benzoic acid trifluoromethyltrimethylsilane trifluoromethylation nucleophilic substitution. The article conveys some information:
The trifluoromethylation of benzoic acids with TMSCF3 was achieved through nucleophilic substitution with the use of anhydrides as an in situ activating reagent. Under the reaction conditions, a wide range of carboxylic acids including the bioactive ones worked well, thus providing a facile and efficient method for preparing aryl trifluoromethyl ketones from the readily available starting materials. In the part of experimental materials, we found many familiar compounds, such as 4-Iodobenzoic acid(cas: 619-58-9Electric Literature of C7H5IO2)
4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.Electric Literature of C7H5IO2 In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com