Liang, Hao; Zhu, Guoxun; Pu, Xiaoyun; Qiu, Liqin published their research in Organic Letters in 2021. The article was titled 《Copper-Catalyzed Enantioselective C-H Arylation between 2-Arylindoles and Hypervalent Iodine Reagents》.Application In Synthesis of 4-Chloro-2-iodoaniline The article contains the following contents:
The copper-catalyzed enantioselective C-H arylation between 2-arylindoles I [R1 = naphthalen-1-yl, thiophen-2-yl, 4-chlorophenyl, etc.; R2 = H, 5-Cl, 6-Br, 5-(4-(trifluoromethoxy)phenyl)] and hypervalent iodine reagents II (R3 = 5-Me, 5-Cl, 3-Cl-5-Me, 5-OMe) has been successfully developed, which provides a convenient and economical route to the highly atroposelective synthesis of axially chiral indole derivatives with a 2-aryl structures III (up to 99% ee). D. functional theory calculations and wave function anal. show that the key “”sandwich”” intermediate leads to high enantioselectivity of the reaction.4-Chloro-2-iodoaniline(cas: 63069-48-7Application In Synthesis of 4-Chloro-2-iodoaniline) was used in this study.
4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Application In Synthesis of 4-Chloro-2-iodoaniline
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com