Synthetic Route of C6H5ClINIn 2022 ,《Recyclable Palladium-Catalyzed Carbonylative Coupling of 2-Iodoanilines, Trimethyl Orthoformate, and Amines: A Practical Synthesis of Quinazolin-4(3H)-ones》 appeared in Synthesis. The author of the article were Li, Jianying; Zhou, Zebiao; Xie, Gang; Cai, Mingzhong. The article conveys some information:
An efficient heterogeneous palladium-catalyzed carbonylative annulation of 2-iodoanilines, tri-Me orthoformate, and amines has been developed. The reaction proceeds smoothly in toluene at 110°C using N,N-diisopropylethylamine (DiPEA) as base and 2 mol% of MCM-41-anchored bidentate phosphine palladium complex [MCM-41-2P-Pd(OAc)2] as catalyst under 10 bar of carbon monoxide and provides a general and practical method for the construction of a wide variety of quinazolin-4(3H)-ones in good to excellent yields from com. easily available starting materials. This heterogenized palladium catalyst can be easily recovered via a simple centrifugation process and reused more than nine times with almost consistent catalytic efficiency. The experimental process involved the reaction of 4-Chloro-2-iodoaniline(cas: 63069-48-7Synthetic Route of C6H5ClIN)
4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Synthetic Route of C6H5ClIN
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com