In 2019,Synlett included an article by Lee, Melissa; Adams, Ashley; Cox, Philip B.; Sanford, Melanie S.. Related Products of 15854-87-2. The article was titled 《Access to 3D Alicyclic Amine-Containing Fragments through Transannular C-H Arylation》. The information in the text is summarized as follows:
In this Letter, authors adapt a recently reported Pd-catalyzed transannular C(sp3)-H arylation of alicyclic amines for applications in fragment-based drug discovery (FBDD). Authors apply this method to the synthesis of a series of 6-arylated 3-azabicyclo[3.1.0]hexanes I (Ar = Ph, 4-ClC6H4, 4-OMeC6H4, 4-Py, 2-Py, etc.) that are rule-of-three compliant fragments. Several modifications were made to the Pd-catalyzed C-H arylation method to enhance its utility in fragment synthesis. These include the use of microwave heating to shorten reaction times to under 1 h and the development of new approaches for directing group cleavage. Finally, authors demonstrate that this fragment library falls within desirable physicochem. space for FBDD applications. After reading the article, we found that the author used 4-Iodopyridine(cas: 15854-87-2Related Products of 15854-87-2)
4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Related Products of 15854-87-2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com