In 2022,Lee, Jaehee; Ju, Xuan; Lee, Miseon; Jiang, Qi; Jang, Hwanjong; Kim, Wan Shin; Wu, Linglin; Williams, Suja; Wang, Xiao-Jun; Zeng, Xingzhong; Payne, Jenna; Han, Zhengxu S. published an article in Organic Letters. The title of the article was 《Copper Catalyzed Regioselective and Stereospecific Aziridine Opening with Pyridyl Grignard Nucleophiles》.Related Products of 15854-87-2 The author mentioned the following in the article:
Copper catalyzed regioselective and stereospecific coupling between aziridines and in-situ generated pyridine Grignard reagents was reported. This method provided β-pyridylethylamines with diverse structures and functionalities from aziridines and iodopyridines. The β-pyridylethylamines were potential scaffolds for the synthesis of biol. active compounds often found in pharmaceuticals. The synthesis of challenging chiral dihydroazaindoles was also achieved through mild one-pot reaction conditions via aziridine opening followed by nucleophilic cyclization.4-Iodopyridine(cas: 15854-87-2Related Products of 15854-87-2) was used in this study.
4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Related Products of 15854-87-2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com