《Amidation of aryl halides with isocyanides using a polymer-supported palladium-N-heterocyclic carbene complex as an efficient, phosphine-free and heterogeneous recyclable catalyst》 was published in Synthesis in 2014. These research results belong to Khairnar, Bhikan J.; Bhanage, Bhalchandra M.. COA of Formula: C6H3ClINO2 The article mentions the following:
The amidation of aryl halides with alkyl/aryl isocyanides to give the corresponding amides using polymer-supported palladium-N-heterocyclic carbene complex (PS-Pd-NHC) as an efficient heterogeneous recyclable catalyst is described. The catalytic system was optimized with respect to various reaction parameters giving excellent yields of the desired products. The catalyst can be easily separated by a simple filtration process and recycled further for up to four consecutive recycle without any loss of activity and selectivity. The protocol is advantageous due to the ease in handling of the catalyst, simple workup procedure, phosphine-free, and effective catalyst recyclability. The synthesis of the target compounds was achieved using polystyrene-supported bis[1,3-dihydro-1-methyl-3-(phenylmethyl)-2H-imidazol-2-ylidene]palladium diacetate as a catalyst. Starting materials included iodobenzene derivatives, bromobenzene derivatives, chlorobenzene derivatives (aryl halides) and isocyanides (isonitriles), such as (isocyano)cyclohexane, (isocyano)benzene, (isocyanomethyl)benzene, 2-isocyano-2-methylpropane (tert-Bu isocyanide). The title compounds thus formed included N-(1,1-dimethylethyl)benzamide, 3-cyano-N-(1,1-dimethylethyl)benzamide (nitrile amide), 4-[[(1,1-dimethylethyl)amino]carbonyl]benzoic acid ester, N-(1,1-dimethylethyl)-3-thiophenecarboxamide (thiophene).1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3COA of Formula: C6H3ClINO2) was used in this study.
1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides.COA of Formula: C6H3ClINO2 The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com