In 2019,Chemical Science included an article by Huy, Peter H.; Mbouhom, Christelle. Computed Properties of C7H5IO2. The article was titled 《Formamide catalyzed activation of carboxylic acids – versatile and cost-efficient amidation and esterification》. The information in the text is summarized as follows:
A novel, broadly applicable method for amide C-N and ester C-O bond formation is presented based on formylpyrrolidine (FPyr) as a Lewis base catalyst. Herein, trichlorotriazine (TCT), which was the most cost-efficient reagent for OH-group activation, was employed in amounts of ≤40 mol% with respect to the starting material (100 mol%). The new approach is distinguished by excellent cost-efficiency, waste-balance (E-factor down to 3) and scalability (up to >80 g). Moreover, high levels of functional group compatibility, which includes acid-labile acetals 3-R(CH2)2OC6H4C(O)R1 (R = 1,3-dioxan-2-yl; R1 = NHCH2CCH, OCH2CCH) and silyl ethers 3-(CH3)3CSi(CH3)2OC6H4C(O)R2 [R2 = OH, (CH3)3CSi(CH3)2O, C6H5CH2N(CH3)], are demonstrated and even peptide C-N bonds can be formed. In comparison to reported amidation procedures using TCT, yields are considerably improved (for instance from 26 to 91%) and esterification is facilitated for the first time in synthetically useful yields. These significant enhancements are rationalized by activation by means of acid chlorides R3C(O)Cl (R3 = Ph, m-tolyl, o-tolyl, benzyl) instead of less electrophilic acid anhydride intermediates. In the experimental materials used by the author, we found 2-Iodobenzoic acid(cas: 88-67-5Computed Properties of C7H5IO2)
2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Computed Properties of C7H5IO2Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com