Hu, Xiao-Qiang; Liu, Zi-Kui; Hou, Ye-Xing; Xu, Ji-Hang; Gao, Yang published an article in 2021. The article was titled 《Merging C-H Activation and Strain-Release in Ruthenium-Catalyzed Isoindolinone Synthesis》, and you may find the article in Organic Letters.Reference of 4-Iodobenzoic acid The information in the text is summarized as follows:
The merger of strain-release of 1,2-oxazetidines I (R = 4-Me, 2,4,5-(OMe)3, 4-Br, etc.) with carboxylic acids 2-R1-3-R2-4-R3-5-R4C6HC(O)OH [R1 = H, Me, Bn, I, etc.; R2 = H, Ph, Br, Me, etc.; R1R2 = -(CH2)4-; R3 = H, Me, t-Bu, Br, etc.; R2R3 = -CH=CH-CH=CH-; R4 = H, OMe] directed C-H activation in catalytic synthesis of isoindolinones II was reported for the first time. This reaction opens a new and sustainable avenue to prepare a range of structurally diverse isoindolinone skeletons II from readily available benzoic acids. The success of late-stage functionalization of some bioactive acids II, and concise synthesis of biol. important skeletons demonstrated its great synthetic potential in drug discovery. Mechanistic studies indicated a plausible C-H activation/β-carbon elimination/intramol. cyclization cascade pathway. In the experimental materials used by the author, we found 4-Iodobenzoic acid(cas: 619-58-9Reference of 4-Iodobenzoic acid)
4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides.Reference of 4-Iodobenzoic acid The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com