In 2022,He, Yuli; Ma, Jiawei; Song, Huayue; Zhang, Yao; Liang, Yong; Wang, You; Zhu, Shaolin published an article in Nature Communications. The title of the article was 《Regio- and enantioselective remote hydroarylation using a ligand-relay strategy》.Synthetic Route of C7H5IO The author mentioned the following in the article:
The design of a single complicated chiral ligand to well-promote each step of an asym. cascade reaction is sometimes a formidable challenge in transition metal catalysis. In this work, a highly regio- and enantioselective Ni-catalyzed migratory hydroarylation relay process has been achieved with the combination of two simple ligands, one which accomplishes chain-walking and the other causing asym. arylation. This formal asym. C(sp3)-H arylation provides direct access to a wide range of structurally diverse chiral 1,1-diarylalkanes, a structural unit found in a number of bioactive mols. The value of this strategy was further demonstrated by the Ni-catalyzed migratory asym. 1,3-arylboration. In the experiment, the researchers used 4-Iodobenzaldehyde(cas: 15164-44-0Synthetic Route of C7H5IO)
4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Synthetic Route of C7H5IO
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com