In 2022,He, Hua-Feng; Wang, Yuwan; Zou, Chun; Tu, Zheng; Xu, Yongquan; Yin, Junfeng published an article in ACS Omega. The title of the article was 《Ag2O-mediated Tandem Reaction between Terminal Alkyne and o-Iodibenzoic Acid: Construction of 3-Ethylideneisobenzofuran-1(3H)-ones》.Application In Synthesis of 2-Iodobenzoic acid The author mentioned the following in the article:
Taking aryl propargyl ether and o-iodibenzoic acid as substrates, a series of aryl cyclolactones bearing an exocyclized C=C bond were constructed with moderate to good yields. Diverse substituent groups could be tolerant in the reaction, which indicated excellent compatibility of the reaction. In this tandem reaction, Ag2O was employed as the media and Et3N was screened as the base to facilitate the reaction. A concise mechanism was proposed on the basis of the expansion of the substrates and theor. anal. Sonogashira type coupling coupled with intramol. nucleophilic addition in one pot to construct the product, 3-ethylideneisobenzofuran-1(3H)-one.2-Iodobenzoic acid(cas: 88-67-5Application In Synthesis of 2-Iodobenzoic acid) was used in this study.
2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Application In Synthesis of 2-Iodobenzoic acid
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com