《Halide-Accelerated Acyl Fluoride Formation Using Sulfuryl Fluoride》 was written by Foth, Paul J.; Malig, Thomas C.; Yu, Hao; Bolduc, Trevor G.; Hein, Jason E.; Sammis, Glenn M.. Safety of 2-Iodobenzoic acid And the article was included in Organic Letters in 2020. The article conveys some information:
Herein, we report a new one-pot sequential method for SO2F2-mediated nucleophilic acyl substitution reactions starting from carboxylic acids. A mechanistic study revealed that SO2F2-mediated acid activation proceeds via the anhydride, which is then converted to the corresponding acyl fluoride. Tetrabutylammonium chloride or bromide accelerate the formation of acyl fluoride. Optimized halide-accelerated conditions were used to synthesize acyl fluorides in 30-80% yields, and esters, amides, and thioesters in 72-96% yields without reoptimization for each nucleophile. Safety: toxic SO2F2. The experimental process involved the reaction of 2-Iodobenzoic acid(cas: 88-67-5Safety of 2-Iodobenzoic acid)
2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Safety of 2-Iodobenzoic acid
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com