《Dibenzofuran Derivatives Inspired from Cercosporamide as Dual Inhibitors of Pim and CLK1 Kinases》 was written by Dao, Viet Hung; Ourliac-Garnier, Isabelle; Loge, Cedric; McCarthy, Florence O.; Bach, Stephane; da Silva, Teresinha Goncalves; Denevault-Sabourin, Caroline; Thiefaine, Jerome; Baratte, Blandine; Robert, Thomas; Gouilleux, Fabrice; Brachet-Botineau, Marie; Bazin, Marc-Antoine; Marchand, Pascal. HPLC of Formula: 626-02-8 And the article was included in Molecules in 2021. The article conveys some information:
Pim kinases (proviral integration site for Moloney murine leukemia virus kinases) are overexpressed in various types of hematol. malignancies and solid carcinomas, and promote cell proliferation and survival. Thus, Pim kinases are validated as targets for antitumor therapy. In this context, our combined efforts in natural product-inspired library generation and screening furnished very promising dibenzo[b,d]furan derivatives derived from cercosporamide. Among them, lead compound 44 was highlighted as a potent Pim-1/2 kinases inhibitor with an addnl. nanomolar IC50 value against CLK1 (cdc2-like kinases 1) and displayed a low micromolar anticancer potency towards the MV4-11 (AML) cell line, expressing high endogenous levels of Pim-1/2 kinases. The design, synthesis, structure-activity relationship, and docking studies are reported herein and supported by enzyme, cellular assays, and Galleria mellonella larvae testing for acute toxicity. After reading the article, we found that the author used 3-Iodophenol(cas: 626-02-8HPLC of Formula: 626-02-8)
3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.HPLC of Formula: 626-02-8
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com