In 2022,Bisht, Narendra; Singh, Prabhakar; Babu, Srinivasarao Arulananda published an article in Synthesis. The title of the article was 《Pd(II)-Catalyzed, Picolinamide-Aided γ-(sp2)-C-H Functionalization of Racemic and Enantiopure α-Methylbenzylamine and Phenylglycinol Scaffolds》.Recommanded Product: 1-Chloro-3-iodobenzene The author mentioned the following in the article:
In this paper, the Pd(II)-catalyzed, picolinamide DG-aided sp2γ-C-H functionalization and expansion of the library of enantiopure α-methylbenzylamine and phenylglycinol scaffolds RCH(CH2R1)NHC(O)R2 (R = Ph, 4-methylphenyl, 2-chlorophenyl, 4-chlorophenyl; R1 = H, OAc; R2 = Ph, pyridin-2-yl, 5-methyl-1,2-oxazol-3-yl, etc.) were reported. The synthesis of a wide range of racemic and enantiopure ortho-C-H arylated, alkylated, brominated, and iodinated α-methylbenzylamine and phenylglycinol scaffolds e.g., N-(1-(4,4”-dimethoxy-[1,1′:3′,1”-terphenyl]-2′-yl)ethyl)picolinamide was shown. Various racemic and Rand S(chiral) sp2γ-C-H functionalized α-methylbenzylamine and phenylglycinol scaffolds were synthesized with good enantiopurities. Racemic and enantiopure α-methylbenzylamine and phenylglycinol derivatives are important building blocks in organic synthesis and medicinal chem. Accordingly, this work contributes to the expansion of the libraries of α-methylbenzylamine and phenylglycinol motifs and substrate scope development through the Pd(II)-catalyzed bidentate directing group picolinamide-aided site-selective C-H activation and functionalization method. The experimental process involved the reaction of 1-Chloro-3-iodobenzene(cas: 625-99-0Recommanded Product: 1-Chloro-3-iodobenzene)
1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Recommanded Product: 1-Chloro-3-iodobenzene
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com