Alayrac, Carole; Witulski, Bernhard published an article in 2021. The article was titled 《Rhodium-catalyzed crossed [2+2+2] cycloaddition with ynamides: key-strategy for the concise total synthesis of 3-oxygenated carbazole alkaloids》, and you may find the article in Heterocycles.Safety of 4-Chloro-2-iodoaniline The information in the text is summarized as follows:
Total syntheses of a set of naturally occurring 3-oxygenated carbazole alkaloids – 6-chlorohyellazole, carazostatin, carbazomycins A and B – are described. The key-strategy underlines a highly chemo- and regioselective rhodium-catalyzed [2+2+2] cyclotrimerization between appropriately tailored yne-ynamides and 1-methoxypropyne that is stirred by the interplay of stereoelectronic and steric effects allowing the introduction of four ring substituents of the natural carbazoles within a single step and making the overall syntheses short and efficient. In the experiment, the researchers used many compounds, for example, 4-Chloro-2-iodoaniline(cas: 63069-48-7Safety of 4-Chloro-2-iodoaniline)
4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Safety of 4-Chloro-2-iodoaniline
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com