Zangade, Sainath; Patil, Pravinkumar published an article in 2021. The article was titled 《Regioselective iodination of activated arenes using KI-DMSO in aqueous hydrochloride》, and you may find the article in Results in Chemistry.Application In Synthesis of 4-Chloro-2-iodoaniline The information in the text is summarized as follows:
The KI-DMSO in aqueous hydrochloride has been utilized for selective iodination of activated arenes, e.g., phenol. The iodination of substrate such as hydroxyacetophenones, amines, phenols, anisole and toluene took place with high regioselectivity and mono-iodination was found to occur. The electron releasing substituents (-CH3, -OCH3, -OH, -NH2) exclusively form para substituted product while ortho-iodination occurred only when para-position was blocked by other substituents. The method is simple and noteworthy for reactive arenes and comprises some advantages such as easy reaction procedure, short reaction time (5-12 min.) and fair to good yield of aryl iodides, e.g., 4-iodophenol (65-90%). The structure of aryl iodide was established on the basis of spectral and elemental data. The experimental part of the paper was very detailed, including the reaction process of 4-Chloro-2-iodoaniline(cas: 63069-48-7Application In Synthesis of 4-Chloro-2-iodoaniline)
4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Application In Synthesis of 4-Chloro-2-iodoaniline
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com