Wong, Alice R.; Fastuca, Nicholas J.; Mak, Victor W.; Kerkovius, Jeffrey K.; Stevenson, Susan M.; Reisman, Sarah E. published their research in ACS Central Science in 2021. The article was titled 《Total Syntheses of the C19 Diterpenoid Alkaloids (-)-Talatisamine, (-)-Liljestrandisine, and (-)-Liljestrandinine by a Fragment Coupling Approach》.SDS of cas: 624-73-7 The article contains the following contents:
The C19 diterpenoid alkaloids (C19 DTAs) are a large family of natural products, many of which modulate the activity of ion channels in vivo and are therefore of interest for the study of neurol. and cardiovascular diseases. The complex architectures of these mols. continue to challenge the state-of-the-art in chem. synthesis, particularly with respect to efficient assembly of their polcyclic ring systems. Here, the authors report the total syntheses of (-)-talatisamine (I), (-)-liljestrandisine (II), and (-)-liljestrandinine (III), three aconitine-type C19 DTAs, using a fragment coupling strategy. Key to this approach is a 1,2-addition/semipinacol rearrangement sequence which efficiently joins two complex fragments and sets an all-carbon quaternary center. In the part of experimental materials, we found many familiar compounds, such as 1,2-Diiodoethane(cas: 624-73-7SDS of cas: 624-73-7)
1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the SimmonsSmith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.SDS of cas: 624-73-7
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com