The author of 《Multi-step continuous flow synthesis of fluconazole》 were Szeto, Judy; Vu, Vi-Anh; Malerich, Jeremiah P.; Collins, Nathan. And the article was published in Journal of Flow Chemistry in 2019. SDS of cas: 1774-47-6 The author mentioned the following in the article:
The development of a flow chem. approach to the anti-fungal fluconazole is described. A continuous, two-reactor, three-step synthesis of fluconazole from 2-chloro-2′,4′-difluoroacetophenone was achieved with no intermediate purification The synthesis has been successfully demonstrated on a Vaportec com. flow chem. system. The experimental process involved the reaction of Trimethylsulfoxonium iodide(cas: 1774-47-6SDS of cas: 1774-47-6)
Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.SDS of cas: 1774-47-6
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com