In 2022,Suri Babu, Undamatla; Singam, Maneesh Kumar Reddy; Kumar, Muniganti Naveen; Nanubolu, Jagadeesh Babu; Sridhar Reddy, Maddi published an article in Organic Letters. The title of the article was 《Palladium-Catalyzed Carbo-Aminative Cyclization of 1,6-Enynes: Access to Naphthyridinone Derivatives》.Safety of 4-Chloro-2-iodoaniline The author mentioned the following in the article:
A general approach to naphthyridinones I [R = H, 8-Me, 7-F, etc.; Ar = Ph, 4-MeC6H4, Bn, etc.; Ar1 = Ph, 4-MeC6H4, 2-thienyl, etc.] was described via Pd-catalyzed annulation of 1,6-enynes with 2-iodoanilines. This protocol represents a rare carbo-aminative annulative cyclization via 6-endo-trig mode, subduing the well documented exo-trig/dig cyclizations. Regioselective aryl palladation of alkyne followed by Heck type intramol. coupling before isomerization were key in realizing this cascade. In addition to this study using 4-Chloro-2-iodoaniline, there are many other studies that have used 4-Chloro-2-iodoaniline(cas: 63069-48-7Safety of 4-Chloro-2-iodoaniline) was used in this study.
4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Safety of 4-Chloro-2-iodoaniline
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com