The author of 《Oxidative organocatalysed enantioselective coupling of indoles with aldehydes that forms quaternary carbon stereocentres》 were Rezayee, Nomaan M.; Lauridsen, Vibeke H.; Naesborg, Line; Nguyen, Thanh V. Q.; Tobiesen, Henriette N.; Joergensen, Karl Anker. And the article was published in Chemical Science in 2019. Recommanded Product: Trimethylsulfoxonium iodide The author mentioned the following in the article:
The first organocatalyzed, metal-free cross-nucleophile coupling of indoles with α-branched aldehydes forming acyclic stereoselective quaternary carbon centers was presented. Applying an amino acid-derived catalyst with suitable organic oxidants afforded the desired enantioenriched indole functionalized products with moderate to excellent yield and enantioselectivity. Two metal-free oxidative protocols employing either DDQ or a sequential approach that uses two organocatalysts to facilitate the use of O2 as the terminal oxidant were disclosed. These methods were compatible with various indoles ranging from electron-rich to -deficient substituents at the C-2,-5,-6 and -7-positions reacting with a series of different α-branched aldehydes. In addition to this study using Trimethylsulfoxonium iodide, there are many other studies that have used Trimethylsulfoxonium iodide(cas: 1774-47-6Recommanded Product: Trimethylsulfoxonium iodide) was used in this study.
Trimethylsulfoxonium iodide(cas: 1774-47-6) is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride. The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.Recommanded Product: Trimethylsulfoxonium iodide
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com