SDS of cas: 189518-78-3On March 20, 2020, Osakabe, Hiroto; Saito, Shota; Miyagawa, Masamichi; Suga, Takuya; Uchikura, Tatsuhiro; Akiyama, Takahiko published an article in Organic Letters. The article was 《Enantioselective Dehydroxyhydrogenation of 3-Indolylmethanols by the Combined Use of Benzothiazoline and Chiral Phosphoric Acid: Construction of a Tertiary Carbon Center》. The article mentions the following:
An enantioselective hydrogen transfer reaction of indolylmethanol, I (R = H, Me, Bn; R1 = Me, i-Pr, Ph, t-Bu; Ar = C6H5, 4-ClC6H4, CCC6H5, etc.; X = H, Me, OMe, Br) which is characterized by the combined use of 2,3-dihydro-2-(2-naphthalenyl)benzothiazole and a newly synthesized chiral phosphoric acid II (Y = 4-Ph-2,6-(i-Pr)2C6H2) has been described. The reaction furnished indoles (R)-III bearing a chiral tertiary carbon center at the 3-position in high to excellent yields and with excellent enantioselectivities, most of which are greater than 95% ee. The chiral indole (R)-III (R = Me; R1 = t-Bu; Ar = 4-BrC6H4; X = H) was converted into an inhibitor of leukotriene production while retaining excellent ee.(R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthalene(cas: 189518-78-3SDS of cas: 189518-78-3) was used in this study.
(R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthalene(cas: 189518-78-3) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.SDS of cas: 189518-78-3
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com