《Cu-catalyzed N-3-Arylation of Hydantoins Using Diaryliodonium Salts》 was published in Organic Letters in 2020. These research results belong to Neerbye Berntsen, Linn; Nova, Ainara; Wragg, David S.; Sandtorv, Alexander H.. Recommanded Product: 1-Bromo-3-iodobenzene The article mentions the following:
A general Cu-catalyzed, regioselective method for the N-3-arylation of hydantoins I (R = R1 = H, Me, Ph; R2 = H, Me), (R)-5-methylhydantoin and (S)-Tetrahydro-1H-pyrrolo[1,2-c]imidazole-1,3(2H)-dione is described. The protocol utilizes aryl(trimethoxyphenyl)iodonium tosylate [2,4,6-(OCH3)3C6H2IR3]+[4-CH3C6H4SO3]- (R3 = Ph, 2-fluorophenyl, 2,3-dihydro-1-benzofuran-5-yl, etc.) as the arylating agent in the presence of triethylamine and a catalytic amount of a simple Cu-salt. The method is compatible with structurally diverse hydantoins I and operates well with neutral aryl groups or aryl groups bearing weakly donating/withdrawing elements. It is also applicable for the rapid diversification of pharmaceutically relevant hydantoins II [Ar = Ph, 4-(methoxycarbonyl)benzen-1-yl, 4-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl]benzen-1-yl] and III. After reading the article, we found that the author used 1-Bromo-3-iodobenzene(cas: 591-18-4Recommanded Product: 1-Bromo-3-iodobenzene)
1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Recommanded Product: 1-Bromo-3-iodobenzene Further, it is involved in the preparation of oxygen-tethered 1,6-enynes.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com