In 2022,Jiang, Rui; Ismiyarto; Abe, Tsukasa; Zhou, Da-Yang; Asano, Kaori; Suzuki, Takayoshi; Sasai, Hiroaki; Suzuki, Takeyuki published an article in Journal of Organic Chemistry. The title of the article was 《Using α- and β-Epimerizations of cis-2,3-Bis(hydroxymethyl)-γ-butyrolactone for the Synthesis of Both Enantiomers of Enterolactone》.Category: iodides-buliding-blocks The author mentioned the following in the article:
The use of the epimerization of cis-2,3-bis(hydroxymethyl)-γ-butyrolactone for the synthesis of enterolactones with anticarcinogenic, anti-inflammatory, antiangiogenic, and antioxidant activity were described . Selective α- or β-epimerization of a γ-butyrolactone was used to selectively synthesize both enantiomers of enterolactone. Theor. and kinetic studies were performed to elucidate the epimerization mechanism. In the experiment, the researchers used many compounds, for example, 3-Iodophenol(cas: 626-02-8Category: iodides-buliding-blocks)
3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Category: iodides-buliding-blocksIodo alkanes participate in a variety of organic synthesis reactions, which include the SimmonsSmith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com