《A proficient microwave synthesis with structure elucidation and the exploitation of the biological behavior of the newly halogenated 3-amino-1H-benzo[f]chromene molecules, targeting dual inhibition of topoisomerase II and microtubules》 was published in Bioorganic Chemistry in 2020. These research results belong to Fouda, Ahmed M.; Okasha, Rawda M.; Alblewi, Fawzia F.; Mora, Ahmed; Afifi, Tarek H.; El-Agrody, Ahmed M.. COA of Formula: C7H5IO The article mentions the following:
A series of β-enamionitriles, linked to the 8-bromo-1H-benzo[f]chromene moieties I (Ar = 2-ClC6H4, 4-IC6H4, 2,6-F2C6H3, etc.), was designed and synthesized under microwave irradiation conditions. Furthermore, the antiproliferative properties were evaluated against the human cancer cell lines MCF-7, HCT-116, and HepG-2 in comparison to the pos. controls Vinblastine and Doxorubicin, employing the viability assay. The obtained results confirmed that most of the tested mols. revealed strong and selective cytotoxic activities against the three cancer cell lines. The most potent cytotoxic compounds I (Ar = 2-ClC6H4, 4-ClC6H4, 4-BrC6H4, 2,3-Cl2C6H3, 2,5-Cl2C6H3) were elected for further examination, such as cell cycle anal., apoptosis assay, Caspase production, and DNA fragmentation. This study also revealed that the desired compounds stimulate cell cycle arrest at the G2/M phases, increase the production of Caspases 3, 8, and 9, and finally cause intrinsic and extrinsic apoptotic cell death. Moreover, these compounds suppress the action of topoisomerase II enzyme and also disrupt the microtubule functions. The SAR study of the synthesized compounds verified that the substitution on the Ph ring of the 1H-benzo[f]chromene nucleus, accompanied with the presence of the bromine atom at the 8-position, increases the ability of these mols. against different cell lines. After reading the article, we found that the author used 4-Iodobenzaldehyde(cas: 15164-44-0COA of Formula: C7H5IO)
4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.COA of Formula: C7H5IO
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com