Fotovic, Luka; Bedekovic, Nikola; Stilinovic, Vladimir published an article in 2021. The article was titled 《Evaluation of Halogenopyridinium Cations as Halogen Bond Donors》, and you may find the article in Crystal Growth & Design.Recommanded Product: 15854-87-2 The information in the text is summarized as follows:
We have performed a database survey and a structural and computational study of the potential and the limitations of halogenopyridinium cations as halogen bond donors. The database survey demonstrated that adding a pos. charge on a halogenopyridine ring increases the probability that the halogen atom will participate in a halogen bond, although for chloropyridines it remains below 60%. Crystal structures of both protonated and N-methylated monohalogenated pyridinium cations revealed that the iodo- and bromopyridinium cations always form halogen-bonding contacts with the iodide anions shorter than the sum of the vdW radii, while chloropyridinium cations mostly participate in longer contacts or fail to form halogen bonds. Although a DFT study of the electrostatic potential has shown that both protonation and N-methylation of halogenopyridines leads to a considerable increase in the ESP of the halogen σ-hole, it is generally not the most pos. site on the cation, allowing for alternate binding sites. After reading the article, we found that the author used 4-Iodopyridine(cas: 15854-87-2Recommanded Product: 15854-87-2)
4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.Recommanded Product: 15854-87-2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com