Dutta, Shubham; Shandilya, Shashank; Yang, Shengwen; Gogoi, Manash Protim; Gandon, Vincent; Sahoo, Akhila K. published an article in 2022. The article was titled 《Cationic-palladium catalyzed regio- and stereoselective syn-1,2-dicarbofunctionalization of unsymmetrical internal alkynes》, and you may find the article in Nature Communications.Safety of 4-Iodobenzoic acid The information in the text is summarized as follows:
The discovery of a regio- and stereoselective syn-1,2-dicarbofunctionalization of unsym. internal alkynes was reported. A cationic Pd-catalyzed three-component coupling of aryl diazonium salts, aryl boronic acids (or olefins) and yne-acetates enables access to all-carbon substituted unsym. olefins. The transformation features broad scope with labile functional group tolerance, building broad chem. space of structural diversity (94 mols.). The value of this synthetic method was demonstrated by the direct transformation of natural products and drug candidates containing yne-acetates, to enable highly substituted structurally complex allyl acetate analogs of biol. important compounds Synthetic versatility of the carboxylate bearing highly substituted olefins was also presented. The reaction outcome was attributed to the in situ formation of stabilized cationic aryl-Pd species, which regulated regioselective aryl-palladation of unsym. yne-acetates. Control experiments reveal the synergy between the carboxylate protecting group and the cationic Pd-intermediate in the regioselectivity and reaction productivity; d. functional theory (DFT) studies rationalize the selectivity of the reaction. In the part of experimental materials, we found many familiar compounds, such as 4-Iodobenzoic acid(cas: 619-58-9Safety of 4-Iodobenzoic acid)
4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Safety of 4-Iodobenzoic acid Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com