《Crystal structure of 1-(2,4,6-trichlorobenzoyloxy) benzotriazole (TCB-OBt): observation of uncommon intermolecular oxygen-oxygen interaction and synthetic application in amidation》 was written by Dolai, Gobinda; Roy, Sayanta; Sen, Srijit; Giri, Rajat Subhra; Mandal, Bhubaneswar. Quality Control of 2-Iodobenzoic acidThis research focused ontrichlorobenzoyloxy benzotriazole preparation crystal structure; benzoic acid amine amidation; aryl amide preparation. The article conveys some information:
The supramol. assembly of a modified Yamaguchi reagent TCB-OBt was investigated. Interestingly, each mol. is interconnected through novel chalcogen-chalcogen (O···O) interaction, π-π stacking and aromatic C-H···O interaction. Hirshfeld surface anal. confirmed the existence of uncommon O···O interactions. A well-organized supramol. layer structure and helical arrangement were observed in the crystal structure. TCB-OBt crystallized in the O-substituted desmotropic form. DFT calculations suggest that the O-substituted form is more stable than the N-substituted form (TCB-(N)-OBt). Morphol. anal. indicates the formation of a fantastically well organized, continuous block-shaped system. Furthermore, the designed reagent works as an efficient activating reagent for amide bond formation with good yields under mild reaction conditions. Use of this reagent avoided intractable acid chlorides and this new mixed-anhydride-based reagent may further be applicable for many other organic transformations. In the part of experimental materials, we found many familiar compounds, such as 2-Iodobenzoic acid(cas: 88-67-5Quality Control of 2-Iodobenzoic acid)
2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.Quality Control of 2-Iodobenzoic acid
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com