《Carboxylic Acid Deoxyfluorination and One-Pot Amide Bond Formation Using Pentafluoropyridine (PFP)》 was written by Brittain, William D. G.; Cobb, Steven L.. SDS of cas: 88-67-5 And the article was included in Organic Letters in 2021. The article conveys some information:
The present work describes the application of pentafluoropyridine (PFP), a cheap com. available reagent, in the deoxyfluorination of carboxylic acids RC(O)OH (R = Et, adamantan-1-yl, Ph, 2-iodophenyl, etc.) to acyl fluorides RC(O)F. The acyl fluorides can be formed from a range of acids under mild conditions. The PFP that can be utilized in a one-pot amide bond formation via in situ generation of acyl fluorides was also demonstrated. This one-pot deoxyfluorination amide bond-forming reaction gives ready access to amides RC(O)N(R1)R2 (R1 = H, Me, Et; R2 = Et, Ph, 3-nitrophenyl, etc.) in yields of ≤94%. In the experiment, the researchers used 2-Iodobenzoic acid(cas: 88-67-5SDS of cas: 88-67-5)
2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.SDS of cas: 88-67-5Iodo alkanes participate in a variety of organic synthesis reactions, which include the SimmonsSmith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com