Braddock, D. Christopher; Davies, Joshua J.; Lickiss, Paul D. published an article in 2022. The article was titled 《Methyltrimethoxysilane (MTM) as a Reagent for Direct Amidation of Carboxylic Acids》, and you may find the article in Organic Letters.Category: iodides-buliding-blocks The information in the text is summarized as follows:
Methyltrimethoxysilane [MTM, CH3Si(OMe)3] was demonstrated an effective, inexpensive, and safe reagent for direct amidation of carboxylic acids with amines. Two simple workup procedures that provided the pure amide product R1C(O)N(R2)R3 [R1 = Ph, Bn, 4-IC6H4, etc.; R2 = Me, Et, Ph, etc.; R3 = H, Me, Et, MeO; R2R3 = (CH2)5, O(CH2)4]without the need for further purification was developed. First employed an aqueous base-mediated annihilation of MTM. Second involved simple product crystallization from the reaction mixture provides a low process mass intensity direct amidation protocol. The experimental part of the paper was very detailed, including the reaction process of 4-Iodobenzoic acid(cas: 619-58-9Category: iodides-buliding-blocks)
4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Category: iodides-buliding-blocks
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com