Alizadeh, Abdolali; Farajpour, Behnaz published their research in Heterocyclic Letters in 2021. The article was titled 《Efficient synthesis of coumarin-based α-acyloxy amides as promising starting materials for diverse post-condensation reactions》.Reference of 4-Iodobenzoic acid The article contains the following contents:
The passerini three-component reaction for the straight-forward synthesis of coumarin-based α-acyloxy amides by employing 4-chloro-3-formylcoumarin were described. This reaction was compatible with various isocyanides and carboxylic acids. Furthermore, synthesized products can be rendered as potential starting materials for divergent post-condensation reactions and was efficiently converted into precious follow-up structures. Simple and available starting materials, catalyst-free selective process, valuable and diverse structures, and easy purification are some highlighted advantages of the synthesized coumarin-based α-acyloxy amides. In addition to this study using 4-Iodobenzoic acid, there are many other studies that have used 4-Iodobenzoic acid(cas: 619-58-9Reference of 4-Iodobenzoic acid) was used in this study.
4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Reference of 4-Iodobenzoic acidIodo alkanes participate in a variety of organic synthesis reactions, which include the SimmonsSmith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com