In 2022,Abdullayev, Shuay; Roy, Rene published an article in Carbohydrate Research. The title of the article was 《Practical non-enzymatic synthesis of propargyl sialyl-α-(2-3′)-lactosamine trisaccharide using minimal protecting groups manipulation》.Safety of 1-Iodopyrrolidine-2,5-dione The author mentioned the following in the article:
The trisaccharide, prop-2-ynyl 5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid-(2→3)-β-D-galactopyranosyl-(1→4)-2-acetamido-2-deoxy-β-D-glucopyranoside has been efficiently synthesized in a few steps without the need of conformationally constrained glycosyl donors and acceptors or enzymes. First, using the known prop-2-ynyl 2-acetamido-2-deoxy-6-O-tert-butyldiphenylsilyl-β-D-glucopyranoside as acceptor and the peracetylated galactosyl trichloroacetimidate as glycosyl donor, followed by protecting groups manipulation, prop-2-ynyl (6-O-tert-butyldiphenylsilyl-β-galactopyranosyl)-(1→4)-2-acetamido-2-deoxy-6-O-tert-butyldiphenylsilyl-β-D-glucopyranoside was synthesized with exclusive O-4 regioselectivity due to steric hindrance of the upper face of the acceptor at O-3. The propargylic aglycon is suitable for chem. ligation using click chem. as reported for its (2→6) sialylated analog. In the experimental materials used by the author, we found 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Safety of 1-Iodopyrrolidine-2,5-dione)
1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Safety of 1-Iodopyrrolidine-2,5-dione
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com