Zhao, Haiwei; Lu, Changhui; Herbert, Simon; Zhang, Wei; Shen, Qilong published their research in Journal of Organic Chemistry in 2021. The article was titled 《Difluoromethylation of Alkyl Bromides and Iodides with TMSCF2H》.Application of 619-58-9 The article contains the following contents:
For the first time, two protocols for direct difluoromethylation of unactivated alkyl bromides and iodides RCH2X [R = 4-phenylbutyl, 3-[(5-methylthiophen-2-yl)carbonyloxy]propyl, dodecyl, etc.; X = Br, I, OTs] were described. Reactions of alkyl iodides with TMSCF2H were mediated by a copper catalyst using CsF as the activator, while reactions of less reactive alkyl bromides required a combination of palladium and a stoichiometric amount of CuI as the catalysts. Preliminary mechanistic studies of the synergistic Pd/Cu-catalyzed difluoromethylation of alkyl bromides suggest that it proceeds likely via a Pd(I)/Pd(III) catalytic cycle. In addition to this study using 4-Iodobenzoic acid, there are many other studies that have used 4-Iodobenzoic acid(cas: 619-58-9Application of 619-58-9) was used in this study.
4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Application of 619-58-9Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com