In 2022,Yan, Songlin; Yu, Weijie; Zhang, Jianye; Fan, Hongmei; Lu, Zhifeng; Zhang, Zhenming; Wang, Tao published an article in Journal of Organic Chemistry. The title of the article was 《Access to gem-Difluoroalkenes via Organic Photoredox-Catalyzed gem-Difluoroallylation of Alkyl Iodides》.Formula: C10H18INO2 The author mentioned the following in the article:
An organic photoredox-catalyzed gem-difluoroallylation of α-trifluoromethyl alkenes CH2=CR(CF3) (R = Br, 4-bromophenyl, thiophen-3-yl, benzodioxol-5-yl, etc.) and 4-(trifluoromethyl)-1,2-dihydronaphthalene with alkyl iodides R1I (R1 = cyclohexyl, oxetan-3-yl, N-boc piperidin-4-yl, etc.) via C-F bond cleavage for the synthesis of gem-difluoroalkene derivatives RC(CH2R1)=CF2 and I is reported. This transition-metal-free transformation utilized a readily available organic dye 4CzIPN as the sole photocatalyst and employed a common chem. N,N,N’,N’-tetramethylethylenediamine as the radical activator of alkyl iodides via halogen-atom transfer. In addition, a variety of iodides, including primary, secondary, and tertiary alkyl iodides, were tolerated and provided good to high yields.tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Formula: C10H18INO2) was used in this study.
tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the SimmonsSmith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Formula: C10H18INO2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com