《Detailed biodistribution of liposomes prepared with polyborane instead of cholesterol for BNCT: effects of PEGylation》 was written by Takeuchi, Issei; Ishizuka, Yukiko; Uchiro, Hiromi; Makino, Kimiko. Safety of 1,2-DiiodoethaneThis research focused ontumor antitumor boron neutron capture therapy liposome PEGylation. The article conveys some information:
Various drug delivery systems for boron neutron capture therapy (BNCT) have been developed. To selectively destroy cancer cells, the high accumulation and selective delivery of 10B into tumor tissue are required. In this study, a polyborane for BNCT with enhanced hydrophobicity was synthesized from decaborane as a boron carrier, and embedded into bare and PEGylated liposomes. These liposomes having diameters of 40-43 nm were injected into tail vein of tumor-bearing mice to evaluate their biodistribution. Boron concentrations in tumor and tumor/blood ratios of the liposomes were reached over 30 μg/g of tissue and over 5 at 8-24 h, resp. At 12 h after injection, PEGylated liposomes were found in tumor with high boron level (130.0 μg/g of tissue). This result showed that the PEGylated liposomes with a diameter of 40 nm were able to achieve efficient intratumoral 10B amount without replacing the 11B with 10B. In the experiment, the researchers used many compounds, for example, 1,2-Diiodoethane(cas: 624-73-7Safety of 1,2-Diiodoethane)
1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Safety of 1,2-Diiodoethane
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com