《Iodinated Choline Transport-Targeted Tracers》 was written by Svec, Pavel; Novy, Zbynek; Kucka, Jan; Petrik, Milos; Sedlacek, Ondrej; Kuchar, Martin; Liskova, Barbora; Medvedikova, Martina; Kolouchova, Kristyna; Groborz, Ondrej; Loukotova, Lenka; Konefal, Rafal L.; Hajduch, Marian; Hruby, Martin. Formula: C6H5IO And the article was included in Journal of Medicinal Chemistry in 2020. The article conveys some information:
We present a novel series of radioiodinated tracers and potential theranostics for diseases accompanied by pathol. function of proteins involved in choline transport. Unlike choline analogs labeled with 11C or 18F that are currently used in the clinic, the iodinated compounds described herein are applicable in positron emission tomog., single-photon emission computed tomog., and potentially in therapy, depending on the iodine isotope selection. Moreover, favorable half-lives of iodine isotopes result in much less challenging synthesis by isotope exchange reaction. Six of the described compounds were nanomolar ligands, and the best compound possessed an affinity 100-fold greater than that of choline. Biodistribution data of 125I-labeled ligands in human prostate carcinoma bearing (PC-3) mice revealed two compounds with a biodistribution profile superior to that of [18F]fluorocholine. In the experiment, the researchers used 3-Iodophenol(cas: 626-02-8Formula: C6H5IO)
3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Formula: C6H5IO
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com