Poh, Jian-Siang; Garcia-Ruiz, Cristina; Zuniga, Andrea; Meroni, Francesca; Blakemore, David C.; Browne, Duncan L.; Ley, Steven V. published the artcile< Synthesis of trifluoromethylated isoxazoles and their elaboration through inter- and intra-molecular C-H arylation>, Recommanded Product: 4-Iodopyridin-3-ol, the main research area is trifluoromethyl nitrile oxide terminal alkyne cycloaddition; isoxazole trifluoromethyl regioselective preparation.
The preparation of a range of trifluoromethylated isoxazole building blocks through the cycloaddition reaction of trifluoromethyl nitrile oxide was reported. It was found that controlling the rate (and therefore concentration) of the formation of the trifluoromethyl nitrile oxide was Critical for the preferential formation of the desired isoxazole products vs. the furoxan dimer. Different conditions were optimized for both aryl- and alkyl-substituted alkynes. In addition, the reactivity at the isoxazole 4-position was briefly explored for these building blocks. Conditions for intermol. C-H arylation, lithiation and electrophile quench, and alkoxylation were all identified with brief substrate scoping that signifies useful tolerance to a range of functionalities. Finally, complementary processes for structural diversification through either intramol. cyclisation or intermol. cross-coupling were developed.
Organic & Biomolecular Chemistry published new progress about [3+2] Cycloaddition reaction (regioselective). 188057-20-7 belongs to class iodides-buliding-blocks, and the molecular formula is C5H4INO, Recommanded Product: 4-Iodopyridin-3-ol.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com