《Cobalt-Catalyzed Selective Unsymmetrical Dioxidation of gem-Difluoroalkenes》 was published in Journal of Organic Chemistry in 2020. These research results belong to Orsi, Douglas L.; Douglas, Justin T.; Sorrentino, Jacob P.; Altman, Ryan A.. Quality Control of 3-Iodophenol The article mentions the following:
Gem-Difluoroalkenes represent valuable synthetic handles for organofluorine chem.; however, most reactions of this substructure proceed through reactive intermediates prone to eliminate a fluorine atom and generate monofluorinated products. Taking advantage of the distinct reactivity of gem-difluoroalkenes, we present a cobalt-catalyzed regioselective unsym. dioxygenation of gem-difluoroalkenes using phenols and mol. oxygen, which retains both fluorine atoms and provides β-phenoxy-β,β-difluorobenzyl alcs. Mechanistic studies suggest that the reaction operates through a radical chain process initiated by Co(II)/O2/phenol and quenched by the Co-based catalyst. This mechanism enables the retention of both fluorine atoms, which contrasts most transition-metal-catalyzed reactions of gem-difluoroalkenes that typically involve defluorination. The experimental process involved the reaction of 3-Iodophenol(cas: 626-02-8Quality Control of 3-Iodophenol)
3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Iodo alkanes participate in a variety of organic synthesis reactions, which include the SimmonsSmith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Quality Control of 3-Iodophenol
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com