In 2022,Mahesh Kumar, Avula; Venkateshwarlu, Rapolu; Tadiparthi, Krishnaji; Rao, B. Venkateswara; Kota Balaji, Shiva Kumar; Raghunadh, Akula; Singh, Shambhu Nath published an article in Synthetic Communications. The title of the article was 《A new facile synthesis of (2S,5S)-5-hydroxypipecolic acid hydrochloride》.Product Details of 1774-47-6 The author mentioned the following in the article:
A simple and efficient synthesis of (2S,5S)-5-Hydroxypipecolic acid hydrochloride was reported. The key features of the synthesis involve the asym. reduction of ketone using (S)-CBS oxazaborolidine and the use of com. available Me pyroglutamate as a starting material. The experimental process involved the reaction of Trimethylsulfoxonium iodide(cas: 1774-47-6Product Details of 1774-47-6)
Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.Product Details of 1774-47-6
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com