《Bronsted Acid-Promoted Diastereoselective [4+1] Cyclization Reaction of Enamides and Sulfoxonium Ylides》 was written by Luo, Nan; Zhan, Zhenzhen; Ban, Zihui; Lu, Guoqiang; He, Jianping; Hu, Fangpeng; Huang, Guosheng. Safety of Trimethylsulfoxonium iodideThis research focused onvinylamide preparation sulfoxonium ylide Bronsted acid catalyst diastereoselective cycloaddition; carbonyl methyloxazoline preparation. The article conveys some information:
A metal-free synthesis of trisubstituted trans-oxazolines using enamides and sulfoxonium ylides was developed. A [4+1] cyclization reaction was realized by the formation of C-C and C-O bonds under mild conditions, wherein the reaction was catalyzed by HClO4. This strategy produced trans-oxazolines in good yields with considerable diastereoselective control and is sufficient for large-scale synthesis. After reading the article, we found that the author used Trimethylsulfoxonium iodide(cas: 1774-47-6Safety of Trimethylsulfoxonium iodide)
Trimethylsulfoxonium iodide(cas: 1774-47-6) is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride. The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.Safety of Trimethylsulfoxonium iodide
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com