In 2022,Koley, Suvajit; Cayton, Kaylee T.; Gonzalez-Montiel, Gisela A.; Yadav, M. Ramu; Orsi, Douglas L.; Intelli, Andrew J.; Cheong, Paul Ha-Yeon; Altman, Ryan A. published an article in Journal of Organic Chemistry. The title of the article was 《Cu(II)-Catalyzed Unsymmetrical Dioxidation of gem-Difluoroalkenes to Generate α,α-Difluorinated-α-phenoxyketones》.Safety of 3-Iodophenol The author mentioned the following in the article:
A Cu-based catalyst system convergently couples gem-difluoroalkenes with phenols under aerobic conditions to deliver α,α-difluorinated-α-phenoxyketones, an unstudied hybrid fluorinated functional group. Composed of α,α-difluorinated ketone and α,α-difluorinated ether moieties, these compounds have rarely been reported as a synthetic intermediate. Computational predictions and later exptl. corroboration suggest that the phenoxy-substituted fluorinated ketone’s sp3-hybridized hydrate form is energetically favored relative to the resp. nonether variant and that perturbation of the electronic character of the ketone can further encourage the formation of the hydrate. The more facile conversion between ketone and hydrate forms suggests that analogs should readily covalently inhibit proteases and other enzymes. Further functionalization of the ketone group enables access to other useful fluorinated functional groups.3-Iodophenol(cas: 626-02-8Safety of 3-Iodophenol) was used in this study.
3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Safety of 3-Iodophenol
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com