Escopy, Samira; Singh, Yashapal; Stine, Keith J.; Demchenko, Alexei V. published their research in Chemistry – A European Journal in 2021. The article was titled 《A Streamlined Regenerative Glycosylation Reaction: Direct, Acid-Free Activation of Thioglycosides》.Synthetic Route of C4H4INO2 The article contains the following contents:
Our group has previously reported that 3,3-difluoroxindole (HOFox) is able to mediate glycosylation via intermediacy of OFox imidates. Thioglycoside precursors were first converted into the corresponding glycosyl bromides that were then converted into the OFox imidates in the presence of Ag2O followed by the activation with catalytic Lewis acid in a regenerative fashion. Reported herein is a direct conversion of thioglycosides via the regenerative approach that bypasses the intermediacy of bromides and eliminates the need for heavy-metal-based promoters. The direct regenerative activation of thioglycosides is achieved under neutral reaction conditions using only 1 equivalent NIS and catalytic HOFox without the acidic additives. In the experimental materials used by the author, we found 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Synthetic Route of C4H4INO2)
1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Synthetic Route of C4H4INO2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com