Bai, Guoyun; O’Connell, Thomas N.; Brodney, Michael A.; Butler, Christopher R.; Czabaniuk, Lara C.; Gilbert, Adam M.; LaChapelle, Erik A.; Li, Chao; McAllister, Laura A.; Ogilvie, Kevin; Philippe, Laurence; Salomon-Ferrer, Romelia; Shapiro, Michael J.; Starr, Jeremy T.; Uccello, Daniel P.; Withka, Jane M.; Yan, Jiangli; Brown, Matthew F. published an article in 2021. The article was titled 《Intramolecular Ring-Opening Decomposition of Aryl Azetidines》, and you may find the article in ACS Medicinal Chemistry Letters.Safety of 4-Iodopyridine The information in the text is summarized as follows:
The ring strain present in azetidines can lead to undesired stability issues. Herein, we described a series of N-substituted azetidines which undergo an acid-mediated intramol. ring-opening decomposition via nucleophilic attack of a pendant amide group. Studies were conducted to understand the decomposition mechanism enabling the design of stable analogs. In addition to this study using 4-Iodopyridine, there are many other studies that have used 4-Iodopyridine(cas: 15854-87-2Safety of 4-Iodopyridine) was used in this study.
4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.Safety of 4-Iodopyridine
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com