In 2022,Kajol, Km; Kumar, Sujeet; Kumar, Amit; Kant, Ruchir; Ramesh, Chintakunta published an article in Asian Journal of Organic Chemistry. The title of the article was 《Palladium-Catalyzed Intramolecular C-H Heteroarylation to Access Fused Tricyclic Oxazolo[4,5-c]Quinolines》.Synthetic Route of C6H5ClIN The author mentioned the following in the article:
Synthesis of fused tricyclic oxazolo[4,5-c]quinolines I (R = 3-Me, 2,5-difluorophenyl, thiophen-2-yl, etc. ; R1 = H, Me, Et, n-Bu, i-Pr, Cl, F; R2 = H, Me) from 2-iodo-N-((2-phenyloxazol-4-yl)methyl)anilines via intramol. C-H heteroarylation in the presence of palladium catalyst under ligand free conditions has been disclosed. Various substituted 2-iodo-N-((2-phenyloxazol-4-yl)methyl)anilines are well tolerated and furnished the products in good yields. The synthetic utility of the resulting mols. has been demonstrated. This method features broad substrate scope, mild reaction conditions, good functional group tolerance, and scalability. After reading the article, we found that the author used 4-Chloro-2-iodoaniline(cas: 63069-48-7Synthetic Route of C6H5ClIN)
4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Synthetic Route of C6H5ClIN
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com