Debrauwer, Vincent; Leito, Ivo; Lokov, Mart; Tshepelevitsh, Sofja; Parmentier, Michael; Blanchard, Nicolas; Bizet, Vincent published an article in 2021. The article was titled 《Synthesis and Physico-Chemical Properties of 2-SF5-(Aza)Indoles, A New Family of SF5-Heterocycles》, and you may find the article in ACS Organic & Inorganic Au.Product Details of 63069-48-7 The information in the text is summarized as follows:
Herein was described a strategy to access (pentafluoro-sulfanyl)indoles I [R = H, 5-Me, 5-OCF3, etc.; R1 = H, Ts] for the first time. The sequence relied on the radical addition of SF5Cl to the alkynyl π-system of 2-ethynyl anilines followed by a cyclization reaction. A telescoped sequence was proposed making this strategy very appealing and reproducible on gram scale. Downstream functionalizations were also demonstrated, allowing an easy diversification of N- and C3-positions. Ames test, pKa, logP and DSC measurements of several fluorinated 2-Rf-indoles were also disclosed. These studies highlighted the strategic advantages that a C2-pentafluorosulfanylated motif impart to a privileged scaffold such as indole. The experimental part of the paper was very detailed, including the reaction process of 4-Chloro-2-iodoaniline(cas: 63069-48-7Product Details of 63069-48-7)
4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Product Details of 63069-48-7
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com