In 2018,Zhou, Fang; Zhu, Jin; Zhang, Yao; Zhu, Shaolin published 《NiH-Catalyzed Reductive Relay Hydroalkylation: A Strategy for the Remote C(sp3)-H Alkylation of Alkenes》.Angewandte Chemie, International Edition published the findings.Application In Synthesis of tert-Butyl 4-iodopiperidine-1-carboxylate The information in the text is summarized as follows:
The terminal-selective, remote C(sp3)-H alkylation of alkenes was achieved by a relay process combining NiH-catalyzed hydrometalation, chain walking, and alkylation. This method enables the construction of unfunctionalized C(sp3)-C(sp3) bonds under mild conditions from two simple feedstock chems., namely olefins and alkyl halides. The practical value of this transformation is further demonstrated by the large-scale and regioconvergent alkylation of isomeric mixtures of olefins at low catalyst loadings. In addition to this study using tert-Butyl 4-iodopiperidine-1-carboxylate, there are many other studies that have used tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Application In Synthesis of tert-Butyl 4-iodopiperidine-1-carboxylate) was used in this study.
tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Application In Synthesis of tert-Butyl 4-iodopiperidine-1-carboxylate
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com